Perinatal S-Adenosylmethionine Supplementation Represses <i>PSEN1</i> Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice

Perinatal S-Adenosylmethionine Supplementation Represses <i>PSEN1</i> Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice

DNA methylation, the main epigenetic modification regulating gene expression, plays a role in the pathophysiology of neurodegeneration. Previous evidence indicates that 5′-flanking hypomethylation of <i>PSEN1</i>, a gene involved in the amyloidogenic pathway in Alzheimer’s disease (AD),...

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Bibliographic Details
Main Authors: Tiziana Raia, Federica Armeli, Rosaria A. Cavallaro, Giampiero Ferraguti, Rita Businaro, Marco Lucarelli, Andrea Fuso
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
presenilin 1
DNA methylation
non-CpG methylation
MIPs (non-CpG methylation-insensitive primers)
Alzheimer’s disease
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/24/14/11675

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https://www.mdpi.com/1422-0067/24/14/11675

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