Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries.

Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries.

BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable for detection, isolation and expansion of tumo...

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Bibliographic Details
Main Authors: Wolfram Osen, Sabine Soltek, Mingxia Song, Barbara Leuchs, Julia Steitz, Thomas Tüting, Stefan B Eichmüller, Xuan-Duc Nguyen, Dirk Schadendorf, Annette Paschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2994730?pdf=render

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http://europepmc.org/articles/PMC2994730?pdf=render

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