Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health

Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health

Chronic kidney disease (CKD) significantly increases cardiovascular risk and mortality, and the accumulation of uremic toxins in the circulation upon kidney failure contributes to this increased risk. We thus performed a screening for potential novel mediators of reduced cardiovascular health starti...

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Bibliographic Details
Main Authors: Eva Harlacher, Corinna Schulte, Sonja Vondenhoff, Philippe Schmitt-Kopplin, Philippe Diederich, Christian Hemmers, Julia Moellmann, Julia Wollenhaupt, Rogier Veltrop, Erik Biessen, Michael Lehrke, Björn Peters, Georg Schlieper, Christoph Kuppe, Jürgen Floege, Vera Jankowski, Nikolaus Marx, Joachim Jankowski, Heidi Noels
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
chronic kidney disease
cardiovascular disease
uremic toxin
cardiomyocyte
drug metabolite
mycophenolate mofetil
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1346475/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2024.1346475/full

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