Whole Blood Profiling of Bacillus Calmette–Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation

Whole Blood Profiling of Bacillus Calmette–Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation

Vaccination of infants with bacillus Calmette–Guérin (BCG) activates both the innate and adaptive arms of the immune response. The antimycobacterial effects of these responses most likely account for the ability of BCG to protect against childhood forms of tuberculosis (TB). There is also evidence f...

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Bibliographic Details
Main Authors: Steven G. Smith, Johanneke Kleinnijenhuis, Mihai G. Netea, Hazel M. Dockrell
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
bacillus Calmette–Guérin
vaccination
heterologous effects
trained immunity
infants
cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00644/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00644/full

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