Advances in the Formulation and Assembly of Non-Cationic Lipid Nanoparticles for the Medical Application of Gene Therapeutics

Advances in the Formulation and Assembly of Non-Cationic Lipid Nanoparticles for the Medical Application of Gene Therapeutics

Lipid nanoparticles have become increasingly popular delivery platforms in the field of gene therapy, but bench-to-bedside success has been limited. Many liposomal gene vectors are comprised of synthetic cationic lipids, which are associated with lipid-induced cytotoxicity and immunogenicity. Natura...

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Bibliographic Details
Main Authors: Richard K. Fisher, Phillip C. West, Samuel I. Mattern-Schain, Michael D. Best, Stacy S. Kirkpatrick, Raymond A. Dieter, Joshua D. Arnold, Michael R. Buckley, Michael M. McNally, Michael B. Freeman, Oscar H. Grandas, Deidra J. H. Mountain
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Nanomaterials
Subjects:
gene therapy
non-viral gene delivery
lipid nanoparticles
non-cationic liposomes
siRNA encapsulation
cell penetrating peptides
Online Access:https://www.mdpi.com/2079-4991/11/3/825

Internet

https://www.mdpi.com/2079-4991/11/3/825

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