Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis

Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis

Chemoresistance is the primary reason for poor prognosis in patients with pancreatic cancer (PC). Recent studies have indicated that ferroptosis may improve chemoresistance, but the underlying mechanisms remain unclear. In this study, significant upregulation of heat shock protein 90α (Hsp90α) expre...

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Bibliographic Details
Main Authors: Liu Bin, Chen Zhiyuan, Li Zhaoxing, Zhao Xinya, Zhang Weigang, Zhang Ao, Wen Longxing, Wang Xiaoming, Zhou Shuying, Qian Daohai
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-08-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
heat shock protein 90α
Keap1-Nrf2 axis
ferroptosis
pancreatic cancer chemoresistance
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024138

Internet

https://www.sciengine.com/doi/10.3724/abbs.2024138

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