Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement

Abstract Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by targeted th...

Full description

Bibliographic Details
Main Authors: Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz‐Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, William R Ryan, Aaron D Tward, Sarah M Knox
Format: Article
Language:English
Published: Springer Nature 2018-03-01
Series:EMBO Molecular Medicine
Subjects:
Online Access:https://doi.org/10.15252/emmm.201708051