Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation

Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation

Understanding the relative contributions of different repair pathways to radiation-induced DNA damage responses remains a challenging issue in terms of studying the radiation injury endpoints. The comparative manifestation of homologous recombination (HR) after irradiation with different doses great...

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Bibliographic Details
Main Authors: Oleg Belov, Anna Chigasova, Margarita Pustovalova, Andrey Osipov, Petr Eremin, Natalia Vorobyeva, Andreyan N. Osipov
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Current Issues in Molecular Biology
Subjects:
DNA double-strand breaks
ionizing radiation
DNA repair pathways
homologous recombination
mathematical modeling
Online Access:https://www.mdpi.com/1467-3045/45/9/465

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https://www.mdpi.com/1467-3045/45/9/465

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