Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1

Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1

Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knockout zebrafish identified an endothelial directional...

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Bibliographic Details
Main Authors: Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Stefan Bonn, Christian Haass, Ulrich Pohl, Eloi Montanez, Bettina Schmid
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TDP-43
angiogenesis
neurodegeneration
zebrafish
ALS
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1169962/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1169962/full

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