Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure model results in improved cardiac function.
| প্রধান লেখক: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Nature Portfolio
2022-05-01
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| মালা: | Nature Communications |
| অনলাইন ব্যবহার করুন: | https://doi.org/10.1038/s41467-022-29703-9 |