Liver Ischemia and Reperfusion Induce Periportal Expression of Necroptosis Executor pMLKL Which Is Associated With Early Allograft Dysfunction After Transplantation

Liver Ischemia and Reperfusion Induce Periportal Expression of Necroptosis Executor pMLKL Which Is Associated With Early Allograft Dysfunction After Transplantation

BackgroundEarly allograft dysfunction (EAD) following liver transplantation (LT) remains a major threat to the survival of liver grafts and recipients. In animal models, it is shown that hepatic ischemia-reperfusion injury (IRI) triggers phosphorylation of Mixed Lineage Kinase domain-like protein (p...

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Bibliographic Details
Main Authors: Shaojun Shi, Eliano Bonaccorsi-Riani, Ivo Schurink, Thierry van den Bosch, Michael Doukas, Karishma A. Lila, Henk P. Roest, Daela Xhema, Pierre Gianello, Jeroen de Jonge, Monique M. A. Verstegen, Luc J. W. van der Laan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
ischemia-reperfusion injury
programmed cell death
non-parenchymal cell
myofibroblast
liver transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.890353/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.890353/full

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