Key Process and Factors Controlling the Direct Translocation of Cell-Penetrating Peptide through Bio-Membrane

Key Process and Factors Controlling the Direct Translocation of Cell-Penetrating Peptide through Bio-Membrane

Cell-penetrating peptide (CPP) can directly penetrate the cytosol (cytolysis) and is expected to be a potent vector for a drug delivery system (DDS). Although there is general agreement that CPP cytolysis is related to dynamic membrane deformation, a distinctive process has yet to be established. He...

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Bibliographic Details
Main Authors: Kazutami Sakamoto, Taku Morishita, Kenichi Aburai, Kenichi Sakai, Masahiko Abe, Ikuhiko Nakase, Shiroh Futaki, Hideki Sakai
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
cell-penetrating peptide (CPP)
direct permeation (cytolysis)
giant unilamellar vesicle (GUV)
CPP adsorption
FITC-octa arginine (FITC-R8)
Online Access:https://www.mdpi.com/1422-0067/21/15/5466

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https://www.mdpi.com/1422-0067/21/15/5466

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