AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons

AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons

Abstract Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central nervous system leading to cerebellar...

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Bibliographic Details
Main Authors: Vanessa Lopes-Rodrigues, Pia Boxy, Eunice Sim, Dong Ik Park, Michael Habeck, Josep Carbonell, Annika Andersson, Diana Fernández-Suárez, Poul Nissen, Anders Nykjær, Lilian Kisiswa
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05979-7

Internet

https://doi.org/10.1038/s41419-023-05979-7

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