Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species

Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species

ABSTRACT Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and cytosine deaminase are known major players in flucytosine resistance by regulating uptake and deamination of 5-FC, respectively. Crypto...

Full description

Bibliographic Details
Main Authors: Dong-Hoon Yang, Ami Khanal Lamichhane, Kyung J. Kwon-Chung, Yun C. Chang
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
Cryptococcus neoformans
Cryptococcus gattii
flucytosine
cytosine permease
cytosine deaminase
nitrogen source
Online Access:https://journals.asm.org/doi/10.1128/mbio.03451-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03451-22

Similar Items