Extracellular Adenosine Triphosphate Binding to P2Y1 Receptors Prevents Glutamate-Induced Excitotoxicity: Involvement of Erk1/2 Signaling Pathway to Suppress Autophagy

Extracellular Adenosine Triphosphate Binding to P2Y1 Receptors Prevents Glutamate-Induced Excitotoxicity: Involvement of Erk1/2 Signaling Pathway to Suppress Autophagy

Glutamate-induced neuroexcitotoxicity could be related to the pathophysiology of some neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease. Extracellular ATP exerts a wide variety of functions, such as attenuating Aβ-mediated toxicity, inhibiting N-Methyl-D-Aspartate (NMD...

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Bibliographic Details
Main Authors: Yiping Xiong, Duanyang Zhou, Kai Zheng, Wenchuan Bi, Yun Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neuroscience
Subjects:
neuroexcitotoxicity
autophagy
extracellular ATP
neuroprotection
Erk1/2 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.901688/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.901688/full

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