Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

Summary: Cholesterol is a major regulator of multiple types of ion channels. Although there is increasing information about cholesterol binding sites, the molecular mechanisms through which cholesterol binding alters channel function are virtually unknown. In this study, we used a combination of Mar...

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Bibliographic Details
Main Authors: Nicolas Barbera, Sara T. Granados, Carlos Guillermo Vanoye, Tatiana V. Abramova, Danielle Kulbak, Sang Joon Ahn, Alfred L. George, Jr., Belinda S. Akpa, Irena Levitan
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Cellular physiology
Molecular biology
Biophysics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222006009

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http://www.sciencedirect.com/science/article/pii/S2589004222006009

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