Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

Abstract Background Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of therapeutic potential obtained so far in multiple sclerosis (MS) with non-...

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Bibliographic Details
Main Authors: Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Neuroinflammation
Subjects:
EAE
TNFR1
TNFR2
Neuroinflammation
Neuroprotection
Online Access:https://doi.org/10.1186/s12974-023-02784-z

Internet

https://doi.org/10.1186/s12974-023-02784-z

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