Sustained S-IgG and S-IgA antibodies to Moderna’s mRNA-1273 vaccine in a Sub-Saharan African cohort suggests need for booster timing reconsiderations

Sustained S-IgG and S-IgA antibodies to Moderna’s mRNA-1273 vaccine in a Sub-Saharan African cohort suggests need for booster timing reconsiderations

IntroductionThis study sought to elucidate the long-term antibody responses to the Moderna mRNA-1273 COVID-19 vaccine within a Ugandan cohort, aiming to contribute to the sparse data on m-RNA vaccine immunogenicity in Sub-Saharan Africa.MethodsWe tracked the development and persistence of the elicit...

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Bibliographic Details
Main Authors: Jennifer Serwanga, Violet Ankunda, Joseph Ssebwana Katende, Claire Baine, Gerald Kevin Oluka, Geoffrey Odoch, Hellen Nantambi, Susan Mugaba, Angella Namuyanja, Ivan Ssali, Peter Ejou, Laban Kato, The COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu, Jackson Sembera, Betty Oliver Auma, Solomon Opio, Ben Gombe
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
long-term immunogenicity
mRNA-1273 vaccine
Sub-Saharan vaccine response
S-IgG and S-IgA antibodies
vaccine-induced immunity
antibody persistence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348905/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348905/full

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