Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice

Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice

Background: Hesperidin (HES) is a flavonoid glycoside found in the tangerine peel and has antioxidant properties. Arsenic trioxide (ATO) is an anti-tumour drug; however, its serious cardiotoxicity limits its clinical application. In addition, the protection of HES against ATO-induced cardiotoxicity...

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Bibliographic Details
Main Authors: Yuxin Jia, Jing Li, Panpan Liu, Mingdong Si, Yanyu Jin, Hongfang Wang, Donglai Ma, Li Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
arsenic trioxide
cardiotoxicity
hesperidin
oxidative stress
p62-Keap1-Nrf2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.758670/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.758670/full

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