The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation

The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation

Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry. Network dysfunction may arise from multifactorial mechanisms in patients fro...

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Bibliographic Details
Main Author: Beulah Leitch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
AMPA receptors
excitatory synapses
feed-forward inhibition
absence epilepsy
corticothalamocortical network
DREADD technology
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.836255/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.836255/full

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