The PI3K-AKT-mTOR signaling pathway mediates the cytoskeletal remodeling and epithelial-mesenchymal transition in bladder outlet obstruction

The PI3K-AKT-mTOR signaling pathway mediates the cytoskeletal remodeling and epithelial-mesenchymal transition in bladder outlet obstruction

Objective: Partial bladder outlet obstruction(pBOO) is the most common cause of lower urinary tract symptoms (LUTS) and significantly affects the quality of life. Long-term pBOO can cause changes in bladder structure and function, referred to as bladder remodeling. The pathogenesis of pBOO-induced b...

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Bibliographic Details
Main Authors: Zhaoxia Zhang, Chenghao Zhanghuang, Tao Mi, Liming Jin, Jiayan Liu, Maoxian Li, Xin Wu, Jinkui Wang, Mujie Li, Zhang Wang, Peng Guo, Dawei He
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
pBOO
Fibrosis
EMT
Cytoskeleton
Remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402308489X

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http://www.sciencedirect.com/science/article/pii/S240584402308489X

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