Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

Genome sequencing studies have revealed a number of cancer-associated mutations in the telomere-binding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic instability, accelerates the onset, and increases t...

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Bibliographic Details
Main Authors: Alexandra M. Pinzaru, Robert A. Hom, Angela Beal, Aaron F. Phillips, Eric Ni, Timothy Cardozo, Nidhi Nair, Jaehyuk Choi, Deborah S. Wuttke, Agnel Sfeir, Eros Lazzerini Denchi
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
POT1
telomere
ATR
replication stress
thymic lymphoma
cutaneous T cell lymphoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305617

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http://www.sciencedirect.com/science/article/pii/S2211124716305617

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