Dissecting Cellular Mechanisms of Long-Chain Acylcarnitines-Driven Cardiotoxicity: Disturbance of Calcium Homeostasis, Activation of Ca<sup>2+</sup>-Dependent Phospholipases, and Mitochondrial Energetics Collapse

Dissecting Cellular Mechanisms of Long-Chain Acylcarnitines-Driven Cardiotoxicity: Disturbance of Calcium Homeostasis, Activation of Ca<sup>2+</sup>-Dependent Phospholipases, and Mitochondrial Energetics Collapse

Long-chain acylcarnitines (LCAC) are implicated in ischemia-reperfusion (I/R)-induced myocardial injury and mitochondrial dysfunction. Yet, molecular mechanisms underlying involvement of LCAC in cardiac injury are not sufficiently studied. It is known that in cardiomyocytes, palmitoylcarnitine (PC)...

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Bibliographic Details
Main Authors: Alexey V. Berezhnov, Evgeniya I. Fedotova, Miroslav N. Nenov, Vitaly A. Kasymov, Oleg Yu. Pimenov, Vladimir V. Dynnik
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
cardiomyocytes
palmitoylcarnitine toxicity
Ca<sup>2+</sup> overload
L-type calcium channels
Krebs cycle
mitochondrial permeability transition pore
Online Access:https://www.mdpi.com/1422-0067/21/20/7461

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https://www.mdpi.com/1422-0067/21/20/7461

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