Surrogate endpoints for overall survival in randomized clinical trials testing immune checkpoint inhibitors: a systematic review and meta-analysis

Surrogate endpoints for overall survival in randomized clinical trials testing immune checkpoint inhibitors: a systematic review and meta-analysis

IntroductionThere is debate on which are the best surrogate endpoint and metric to capture treatment effect on overall survival (OS) in RCTs testing immune-checkpoint inhibitors (ICIs).MethodsWe systematically searched for RCTs testing ICIs in patients with advanced solid tumors. Inclusion criteria...

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Bibliographic Details
Main Authors: Isabella Sala, Eleonora Pagan, Laura Pala, Chiara Oriecuia, Marco Musca, Claudia Specchia, Tommaso De Pas, Javier Cortes, Giuseppe Giaccone, Michael Postow, Richard D. Gelber, Vincenzo Bagnardi, Fabio Conforti
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
surrogate
randomized clinical trial
immune check inhibitor (ICI)
methodology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1340979/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1340979/full

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