HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma

HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma

Abstract Background Although the aberrant activation of NOTCH1 pathway causes a malignant progression of renal cell carcinoma (RCC), the precise molecular mechanisms behind the potential action of pro-oncogenic NOTCH1/HES1 axis remain elusive. Here, we examined the role of tumor suppressive miR-138–...

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Bibliographic Details
Main Authors: Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei, Zhaowei Jiang, Yongze Ouyang, Toshinori Ozaki, Meng Yu, Yuyan Zhu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HES1
miR-138–2
NOTCH
Renal cell carcinoma
Proliferation
Invasion
Online Access:https://doi.org/10.1186/s13046-023-02625-0

Internet

https://doi.org/10.1186/s13046-023-02625-0

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