Mitochondrial and redox modifications in early stages of Huntington's disease

Mitochondrial and redox modifications in early stages of Huntington's disease

Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and can be detected in vivo is still unclear. In...

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Bibliographic Details
Main Authors: Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Redox Biology
Subjects:
64Cu]-ATSM PET
Human skin fibroblasts
YAC128 mice
Reactive oxygen species
Mitochondrial bioenergetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001963

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http://www.sciencedirect.com/science/article/pii/S2213231722001963

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