Agent-Based Modeling of Autosomal Recessive Deafness 1A (DFNB1A) Prevalence with Regard to Intensity of Selection Pressure in Isolated Human Population

Agent-Based Modeling of Autosomal Recessive Deafness 1A (DFNB1A) Prevalence with Regard to Intensity of Selection Pressure in Isolated Human Population

An increase in the prevalence of autosomal recessive deafness 1A (DFNB1A) in populations of European descent was shown to be promoted by assortative marriages among deaf people. Assortative marriages became possible with the widespread introduction of sign language, resulting in increased genetic fi...

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Bibliographic Details
Main Authors: Georgii P. Romanov, Anna A. Smirnova, Vladimir I. Zamyatin, Aleksey M. Mukhin, Fedor V. Kazantsev, Vera G. Pshennikova, Fedor M. Teryutin, Aisen V. Solovyev, Sardana A. Fedorova, Olga L. Posukh, Sergey A. Lashin, Nikolay A. Barashkov
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biology
Subjects:
agent-based computer modeling
hereditary deafness
<i>GJB2</i>
genetic fitness
assortative mating
sign language
Online Access:https://www.mdpi.com/2079-7737/11/2/257

Internet

https://www.mdpi.com/2079-7737/11/2/257

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