Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs.

Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs.

The exogenous small interfering RNA (exo-siRNA) pathway is a key antiviral mechanism in the Aedes aegypti mosquito, a widely distributed vector of human-pathogenic arboviruses. This pathway is induced by virus-derived double-stranded RNAs (dsRNA) that are cleaved by the ribonuclease Dicer 2 (Dcr2) i...

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Bibliographic Details
Main Authors: Rommel J Gestuveo, Rhys Parry, Laura B Dickson, Sebastian Lequime, Vattipally B Sreenu, Matthew J Arnold, Alexander A Khromykh, Esther Schnettler, Louis Lambrechts, Margus Varjak, Alain Kohl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010202&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010202&type=printable

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