Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition

Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition

Peroxisome proliferator-activated receptors (PPARs) play crucial roles in glucose and lipid metabolism and inflammation. Sanguinarine is a natural product that is isolated from Sanguinaria Canadensis, a potential therapeutic agent for intervention in chronic diseases. In this study, biochemical and...

Full description

Bibliographic Details
Main Authors: Siyu Tian, Rui Wang, Shuming Chen, Jialing He, Weili Zheng, Yong Li
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
dual agonist
crystal structure
pharmacophore
nuclear receptors
peroxisome proliferator-activated receptors
Online Access:https://www.mdpi.com/1420-3049/26/19/6012

Internet

https://www.mdpi.com/1420-3049/26/19/6012

Similar Items