Preferential interaction with c-MYC quadruplex DNA mediates the cytotoxic activity of a nitro-flavone derivative in A375 cells

Preferential interaction with c-MYC quadruplex DNA mediates the cytotoxic activity of a nitro-flavone derivative in A375 cells

G-quadruplex DNAs (G4 DNAs) are emerging as promising anticancer drug targets due to their presence in the promoter regions of different oncogenes. Utilizing different spectroscopic techniques like UV–Vis absorption titration, thermal denaturation, spectrofluorimetric titration, fluorescence displac...

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Bibliographic Details
Main Authors: Anindita Mitra, Sudipta Bhowmik, Rita Ghosh
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Journal of Photochemistry and Photobiology
Subjects:
Flavone derivative
UV–Vis absorption spectroscopy
Fluorescence spectroscopy
Circular dichroism spectroscopy
Molecular docking
In cellulo studies
Online Access:http://www.sciencedirect.com/science/article/pii/S266646902100018X

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http://www.sciencedirect.com/science/article/pii/S266646902100018X

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