Endothelial Dec1-PPARγ Axis Impairs Proliferation and Apoptosis Homeostasis Under Hypoxia in Pulmonary Arterial Hypertension

Endothelial Dec1-PPARγ Axis Impairs Proliferation and Apoptosis Homeostasis Under Hypoxia in Pulmonary Arterial Hypertension

Background: The hypoxia-induced pro-proliferative and anti-apoptotic characteristics of pulmonary arterial endothelial cells (PAECs) play critical roles in pulmonary vascular remodeling and contribute to hypoxic pulmonary arterial hypertension (PAH) pathogenesis. However, the mechanism underlying th...

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Bibliographic Details
Main Authors: Xiaoming Li, Chengcheng Liu, Wenwen Qi, Qiu Meng, Hui Zhao, Zhenxiao Teng, Runtong Xu, Xinhao Wu, Fangyuan Zhu, Yiming Qin, Miaoqing Zhao, Fenglei Xu, Ming Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypoxia
differentiated embryo-chondrocyte expressed gene 1 (Dec1)
peroxisome proliferative activated receptor-γ (PPARγ)
proliferation
apoptosis
pulmonary arterial hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.757168/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.757168/full

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