ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

Abstract Cellular response to protein misfolding underlies multiple diseases. Collagens are the most abundant vertebrate proteins, yet little is known about cellular response to misfolding of their procollagen precursors. Osteoblasts (OBs)—the cells that make bone—produce so much procollagen that it...

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Bibliographic Details
Main Authors: Laura Gorrell, Elena Makareeva, Shakib Omari, Satoru Otsuru, Sergey Leikin
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Advanced Science
Subjects:
ATF5
cell stress
collagen
osteoblast
osteogenesis imperfecta
HSPA9/mt‐Hsp70/GRP75
Online Access:https://doi.org/10.1002/advs.202201273

Internet

https://doi.org/10.1002/advs.202201273

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