Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin

Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin

Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with deregulated gene expression and impaired tissue functionality, leading to the well-known skin aging phenotype. Searching for small molecules, whi...

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Bibliografske podrobnosti
Main Authors: Cassandra Falckenhayn, Agata Bienkowska, Jörn Söhle, Katrin Wegner, Guenter Raddatz, Boris Kristof, Dirk Kuck, Ralf Siegner, Ronny Kaufmann, Julia Korn, Sascha Baumann, Daniela Lange, Andreas Schepky, Henry Völzke, Lars Kaderali, Marc Winnefeld, Frank Lyko, Elke Grönniger
Format: Article
Jezik:English
Izdano: Frontiers Media S.A. 2024-03-01
Serija:Frontiers in Aging
Teme:
dihydromyricetin
DNMT1 inhibition
DNA methylation
DNAm age clock
skin
rejuvenation
Online dostop:https://www.frontiersin.org/articles/10.3389/fragi.2023.1258184/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2023.1258184/full

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