IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis

IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis

Abstract Objectives Osteoblasts are derived from Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs), which play an indispensable role in bone formation. In this study, the authors aim to investigate the role of IRF4 in the osteogenic differentiation of BM-MSCs and its potential molecular mechanis...

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Bibliographic Details
Main Authors: Xuepu Zhang, Yue Zhang, Limin Yang, Yuexin Wu, Xiaohu Ma, Gang Tong, Zhaoliang Ban, Haosen Zhao
Format: Article
Language:English
Published: Elsevier España 2022-05-01
Series:Clinics
Subjects:
Osteoporosis
BM-MSCs
Osteogenic differentiation
miR-636
DOCK9
ALP
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322022000100212&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322022000100212&tlng=en

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