Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs

Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts. To obtain cpIPP the “northern” ribose of cADPR was replaced by a pentyl chain...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Stefano D’Errico, Nicola Borbone, Bruno Catalanotti, Agnese Secondo, Tiziana Petrozziello, Ilaria Piccialli, Anna Pannaccione, Valeria Costantino, Luciano Mayol, Gennaro Piccialli, Giorgia Oliviero
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: MDPI AG 2018-03-01
মালা:Marine Drugs
বিষয়গুলি:
cADPR
calcium mobilization
PC12 neuronal cells
cyclization
nucleotides
macrocycle conformational sampling
অনলাইন ব্যবহার করুন:http://www.mdpi.com/1660-3397/16/3/89

আন্তর্জাল

http://www.mdpi.com/1660-3397/16/3/89

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