Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs

Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts. To obtain cpIPP the “northern” ribose of cADPR was replaced by a pentyl chain...

Podrobná bibliografie
Hlavní autoři:	Stefano D’Errico, Nicola Borbone, Bruno Catalanotti, Agnese Secondo, Tiziana Petrozziello, Ilaria Piccialli, Anna Pannaccione, Valeria Costantino, Luciano Mayol, Gennaro Piccialli, Giorgia Oliviero
Médium:	Článek
Jazyk:	English
Vydáno:	MDPI AG 2018-03-01
Edice:	Marine Drugs
Témata:	cADPR calcium mobilization PC12 neuronal cells cyclization nucleotides macrocycle conformational sampling
On-line přístup:	http://www.mdpi.com/1660-3397/16/3/89

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