Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2). Also, estrogen has been known to regulate AQP2. Consistently, we previously demonstrated that tamoxifen (TAM), a selective estrogen receptor modulator, attenuates the downr...

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Bibliographic Details
Main Authors: Stine Julie Tingskov, Hyo-Jung Choi, Mikkel R. Holst, Shan Hu, Chunling Li, Weidong Wang, Jørgen Frøkiær, Lene N. Nejsum, Tae-Hwan Kwon, Rikke Nørregaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
Aquaporin-2
inner medullary collecting duct
tamoxifen
unilateral ureteral obstruction
vasopressin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00948/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00948/full

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