Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts

Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2). Also, estrogen has been known to regulate AQP2. Consistently, we previously demonstrated that tamoxifen (TAM), a selective estrogen receptor modulator, attenuates the downr...

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Detalles Bibliográficos
Autores principales: Stine Julie Tingskov, Hyo-Jung Choi, Mikkel R. Holst, Shan Hu, Chunling Li, Weidong Wang, Jørgen Frøkiær, Lene N. Nejsum, Tae-Hwan Kwon, Rikke Nørregaard
Formato: Artículo
Lenguaje:English
Publicado: Frontiers Media S.A. 2019-08-01
Colección:Frontiers in Physiology
Materias:
Aquaporin-2
inner medullary collecting duct
tamoxifen
unilateral ureteral obstruction
vasopressin
Acceso en línea:https://www.frontiersin.org/article/10.3389/fphys.2019.00948/full

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