Astaxanthin Protects against Hyperglycemia-Induced Oxidative and Inflammatory Damage to Bone Marrow and to Bone Marrow-Retained Stem Cells and Restores Normal Hematopoiesis in Streptozotocin-Induced Diabetic Mice

Astaxanthin Protects against Hyperglycemia-Induced Oxidative and Inflammatory Damage to Bone Marrow and to Bone Marrow-Retained Stem Cells and Restores Normal Hematopoiesis in Streptozotocin-Induced Diabetic Mice

Hyperglycemia has various adverse health effects, some of which are due to chronic oxidative and inflammatory impairment of bone marrow (BM), hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). Astaxanthin (ASTX) has been shown to ameliorate hyperglycemia-associated systemic complica...

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Bibliographic Details
Main Authors: Govinda Bhattarai, Han-Sol So, Tae-Geum Kim, Thi Thu Trang Kieu, Yeon-Woo Kim, Ku-Ri Yang, Jeong-Chae Lee, Sung-Ho Kook, Young-Mi Jeon
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antioxidants
Subjects:
astaxanthin
hyperglycemic complications
bone marrow microenvironment
stem cell senescence
hematopoiesis
bone mass accrual
Online Access:https://www.mdpi.com/2076-3921/11/12/2321

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https://www.mdpi.com/2076-3921/11/12/2321

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