Membrane-Driven Dimerization of the Peripheral Membrane Protein KRAS: Implications for Downstream Signaling

Membrane-Driven Dimerization of the Peripheral Membrane Protein KRAS: Implications for Downstream Signaling

Transient homo-dimerization of the RAS GTPase at the plasma membrane has been shown to promote the mitogen-activated protein kinase (MAPK) signaling pathway essential for cell proliferation and oncogenesis. To date, numerous crystallographic studies have focused on the well-defined GTPase domains of...

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Bibliographic Details
Main Author: Ki-Young Lee
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
KRAS
peripheral membrane protein
dimerization
nanodisc
paramagnetic relaxation enhancement (PRE)
Online Access:https://www.mdpi.com/1422-0067/25/5/2530

Internet

https://www.mdpi.com/1422-0067/25/5/2530

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