Epigenome-based splicing prediction using a recurrent neural network.

Alternative RNA splicing provides an important means to expand metazoan transcriptome diversity. Contrary to what was accepted previously, splicing is now thought to predominantly take place during transcription. Motivated by emerging data showing the physical proximity of the spliceosome to Pol II,...

Full description

Bibliographic Details
Main Authors: Donghoon Lee, Jing Zhang, Jason Liu, Mark Gerstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008006