Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis

T cells reacting to self-components can promote tissue damage when escaping tolerogenic control mechanisms which may result in autoimmune disease. The current treatments for these disorders are not antigen (Ag) specific and can compromise host immunity through chronic suppression. We have previously...

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Bibliographic Details
Main Authors: Robert A. LaMothe, Pallavi N. Kolte, Trinh Vo, Joseph D. Ferrari, Tracy C. Gelsinger, Jodie Wong, Victor T. Chan, Sinthia Ahmed, Aditi Srinivasan, Patrick Deitemeyer, Roberto A. Maldonado, Takashi K. Kishimoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
nanoparticles
immunological tolerance
rapamycin
regulatory T cells
experimental autoimmune encephalomyelitis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00281/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00281/full

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