The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics

The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics

The cytoskeleton has a primary role in cardiomyocyte function, including the response to mechanical stimuli and injury. The small heat shock protein 20 (Hsp20) conveys protective effects in cardiac muscle that are linked to serine-16 (Ser16) Hsp20 phosphorylation by stress-induced PKA, but the link...

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Bibliographic Details
Main Authors: Elizabeth Vafiadaki, Demetrios A. Arvanitis, Aristides G. Eliopoulos, Evangelia G. Kranias, Despina Sanoudou
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Hsp20 phosphorylation
14-3-3
actin cytoskeleton
cardiac muscle
cardiomyopathy
heart failure
Online Access:https://www.mdpi.com/1422-0067/21/24/9572

Internet

https://www.mdpi.com/1422-0067/21/24/9572

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