Construction of tetravalent bispecific Tandab (CD3/BCMA)-secreting human umbilical cord mesenchymal stem cells and its efficiency in the treatment of multiple myeloma

Construction of tetravalent bispecific Tandab (CD3/BCMA)-secreting human umbilical cord mesenchymal stem cells and its efficiency in the treatment of multiple myeloma

Abstract Background Highly efficient targeted therapy is urgently needed for multiple myeloma (MM). Mesenchymal stem cells (MSCs) are an attractive candidate of cell-based, targeted therapy due to their inherent tumor tropism. However, there is still no MSCs-based tandem diabody for treating MM. Met...

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Bibliographic Details
Main Authors: Mengshang Xiong, Chunfang Kong, Yang Lu, Jiaojun Liu, Weirong Ding, Tingting Zhang, Wei Zuo, Lixia Cao, Qiling Lu, Anna Li, Chaoyu Li, Liting Ding, Yutao Yan, Bo Ke, Caishui Wan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
MSCs
T-cell bispecific antibodies
CD3
BCMA
Multiple myeloma
Online Access:https://doi.org/10.1186/s13287-025-04212-w

Internet

https://doi.org/10.1186/s13287-025-04212-w

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