Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis.

Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis.

The mammalian nuclear hormone receptors LRH1 (NR5A2) and SF1 (NR5A1) are close paralogs that can bind the same DNA motif and play crucial roles in gonadal development and function. Lrh1 is essential for follicle development in the ovary and has been proposed to regulate steroidogenesis in the testis...

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Bibliographic Details
Main Authors: Kellie S Agrimson, Anna Minkina, Danielle Sadowski, Andrew Wheeler, Mark W Murphy, Micah D Gearhart, Vivian J Bardwell, David Zarkower
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010088

Internet

https://doi.org/10.1371/journal.pgen.1010088

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