Use of a small peptide fragment as an inhibitor of insulin fibrillation process: a study by high and low resolution spectroscopy.

Use of a small peptide fragment as an inhibitor of insulin fibrillation process: a study by high and low resolution spectroscopy.

A non-toxic, nine residue peptide, NIVNVSLVK is shown to interfere with insulin fibrillation by various biophysical methods. Insulin undergoes conformational changes under certain stress conditions leading to amyloid fibrils. Fibrillation of insulin poses a problem in its long-term storage, reducing...

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Bibliographic Details
Main Authors: Victor Banerjee, Rajiv K Kar, Aritreyee Datta, Krupakar Parthasarathi, Subhrangsu Chatterjee, Kali P Das, Anirban Bhunia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756998?pdf=render

Internet

http://europepmc.org/articles/PMC3756998?pdf=render

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