Comparison of the Impact of Pharmacogenetic Variability on the PK of Slow Release and Immediate Release Tacrolimus Formulations

Comparison of the Impact of Pharmacogenetic Variability on the PK of Slow Release and Immediate Release Tacrolimus Formulations

Tacrolimus-modified release formulations allow for once-daily dosing, and adherence is better compared to the twice-daily immediate release formulation. When patients are switched from one formulation to another, variable changes in drug concentrations are observed. Current data suggest that the cha...

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Bibliographic Details
Main Authors: Teun van Gelder, Oumaima Etsouli, Dirk Jan Moes, Jesse J. Swen
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Genes
Subjects:
tacrolimus
pharmacokinetics
CYP3A
immediate release
modified release
switching
Online Access:https://www.mdpi.com/2073-4425/11/10/1205

Internet

https://www.mdpi.com/2073-4425/11/10/1205

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