Identification and characterization of a novel chromosomal aminoglycoside 3’-O-phosphotransferase, APH(3′)-Id, from Kluyvera intermedia DW18 isolated from the sewage of an animal farm

Identification and characterization of a novel chromosomal aminoglycoside 3’-O-phosphotransferase, APH(3′)-Id, from Kluyvera intermedia DW18 isolated from the sewage of an animal farm

BackgroundAminoglycosides, as important clinical antimicrobials, are used as second-line drugs for treating multidrug-resistant tuberculosis or combined with β-lactam drugs for treating severe infections such as sepsis. Aminoglycoside-modifying enzyme (AME) is the most important mechanism of aminogl...

Full description

Bibliographic Details
Main Authors: Yuning Sha, Naru Lin, Guozhi Zhang, Yuan Zhang, Jingxuan Zhao, Junwan Lu, Tingting Zhu, Xueya Zhang, Qiaoling Li, Hailin Zhang, Xi Lin, Kewei Li, Qiyu Bao, Dong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Microbiology
Subjects:
Kluyvera intermedia
resistance gene
APH(3′)-Id
aminoglycoside 3’-O-phosphotransferase
kinetic parameter
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1224464/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1224464/full

Similar Items