HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via <i>PHLDA1</i> Induction

HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via <i>PHLDA1</i> Induction

The downregulation of Pleckstrin Homology-Like Domain family A member 1 (PHLDA1) expression mediates resistance to targeted therapies in receptor tyrosine kinase-driven cancers. The restoration and maintenance of PHLDA1 levels in cancer cells thus constitutes a potential strategy to circumvent resis...

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Bibliographic Details
Main Authors: Natasha S. Clayton, Edward P. Carter, Abbie E. Fearon, James A. Heward, Lucía Rodríguez Fernández, Lina Boughetane, Edmund H. Wilkes, Pedro R. Cutillas, Richard P. Grose
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
PHLDA1
TDAG51
HER2
lapatinib
breast cancer
drug resistance
Online Access:https://www.mdpi.com/1422-0067/24/7/6228

Internet

https://www.mdpi.com/1422-0067/24/7/6228

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