CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

BACKGROUND: Glioblastoma (GBM) was shown to relapse faster and displayed therapeutic resistance to antiangiogenic therapies (AATs) through an alternative tumor cell-driven mechanism of neovascularization called vascular mimicry (VM). We identified highly upregulated interleukin 8 (IL-8)-CXCR2 axis i...

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Bibliographic Details
Main Authors: Kartik Angara, Thaiz F. Borin, Mohammad H. Rashid, Iryna Lebedyeva, Roxan Ara, Ping-Chang Lin, ASM Iskander, Roni J. Bollag, Bhagelu R. Achyut, Ali S. Arbab
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558618303798